CNS-5161 hydrochloride

CAS No. 160756-38-7

CNS-5161 hydrochloride ( CNS 5161A )

Catalog No. M26124 CAS No. 160756-38-7

CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1512 Get Quote
10MG 2043 Get Quote
25MG 3033 Get Quote
50MG 4077 Get Quote
100MG 5517 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    CNS-5161 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
  • Description
    CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.(In Vitro):CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.(In Vivo):In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and has a neuroprotective effect following hypoxic/ischaemic brain injury in neonatal rats.
  • Synonyms
    CNS 5161A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bacterial; Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    160756-38-7
  • Formula Weight
    388.4
  • Molecular Formula
    C16H19Cl2N3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CSc1cccc(c1)N(C)C(=N)Nc1cc(SC)ccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes. Med Chem. 2011 Jul;7(4):250-6.
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