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CNS-5161 hydrochloride
CAS No. 160756-38-7
CNS-5161 hydrochloride( CNS 5161A )
Catalog No. M26124 CAS No. 160756-38-7
CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1512 | Get Quote |
|
| 10MG | 2043 | Get Quote |
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| 25MG | 3033 | Get Quote |
|
| 50MG | 4077 | Get Quote |
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| 100MG | 5517 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCNS-5161 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
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DescriptionCNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.(In Vitro):CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.(In Vivo):In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and has a neuroprotective effect following hypoxic/ischaemic brain injury in neonatal rats.
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In VitroCNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.
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In VivoIn the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats.
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SynonymsCNS 5161A
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PathwayOthers
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TargetOther Targets
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RecptorBacterial| Parasite
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Research Area——
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Indication——
Chemical Information
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CAS Number160756-38-7
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Formula Weight388.37
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Molecular FormulaC16H19Cl2N3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.CSc1cccc(c1)N(C)C(=N)Nc1cc(SC)ccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes. Med Chem. 2011 Jul;7(4):250-6.
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